4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) - APICMO Ko APICMO he kaiwhakarato o te hanganga ritenga ahumahi me te kirimana R & D Kāinga Mō Us To tatou Tikanga to tatou kiritaki To tatou Team to tatou Ratonga Rangahau me te kirimana R & D Te ahumahi iti me te ahumahi nui Poraka whare mo te kitenga raau taero Tukatuka R & D me te whanaketanga huarahi hou Tukuangé press Products Whakapā mai Kāinga Mō Us To tatou Tikanga to tatou kiritaki To tatou Team to tatou Ratonga Rangahau me te kirimana R & D Te ahumahi iti me te ahumahi nui Poraka whare mo te kitenga raau taero Tukatuka R & D me te whanaketanga huarahi hou Tukuangé press Products Whakapā mai Hua Products > 4-Chloro-6,7-dimethoxyquinazoline(13790-39-1) 4-Chloro-6,7-dimethoxyquinazoline(13790-39-1) Kei te noho tenei hua (s) i runga i te kirimana APICMO. Kei a tatou te kaha ki te whakaputa, ki te whakahiato me te waihanga i te rahi o te 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) me te whakahaere i te kounga kounga i raro i nga whakaritenga hangahanga CGMP. Kāwai: Heterocycles Whakaahuatanga Reviews (1) Whakaahuatanga 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) video n »črā Ko te hunga mate ki te mate pukupuku mate pukupuku iti (NSCLC) me nga whakawhitinga whakatairanga-a-raanei o te ira kaitango-whakawhitinga ira (eGFR) ka whakautu ki nga Inhibitors EGFR tyrosine kinase (EGFR-TKI). Ko te β-Catenin he tohu matua o te tohu Wnt / β-Catenin me te mea he nui te tocogene e uru ana ki te pathogenesis me te haere tonu o nga pukupuku kino, ina koa nga pukupuku mate pukupuku. I kitea ko nga raupapatanga NSCLC kua whakaekea e te EGFR-teitei o te whakaaturanga o te β-Catenin, he rite ki nga raina waea me te momo EGFR momo kararehe, a XAV939 (he Inhibitor β-Catenin) i whakanui ake i nga ahuatanga ki te EGFR-TKI i roto i te EGFR Nga raina waea NSCLC. I roto i nga raina waea NSCLC i whakaekea e EGFR me te whakawhitinga threonine-to-methionine i te codon 790 (T790M), kua whakarei ake te XAV939 i te hiranga o nga pūtau ki te EGFR-TKI engari kaore i te EGFR-TKI. Ko te whakakotahi o te XAV939 me te EGFR-TKI e kaha ana te whakakore i te tohu β-Catenin me te kaha whakaiti i te phosphorylation o te EGFR, i whakaritea ki te whakamahi i te EGFR-TKI anake, e whakaatu ana he hononga i waenga i te EGFR me te tohu β-Catenin. Ko nga taapene-rite o nga raina waea EGFR-whakaheke i te whakawhitinga o te T790M kua whakakorehia e XAV939 me te BIBW2992 (he EGFR-TKI e kore e taea te whakahoki). I tua atu, ko nga taonga koiora-rite nga mea tino kaha i te whakakorehia e te huinga o nga kaiwhakahaere tokorua. I whakaaturia e te rangahau xenograft ka whakanui te β-Catenin knockdown i te painga antitumor o te BIBW2992 i roto i te raina waea NSCLC whakawhitihia e EGFR e kawe ana i te whakawhitinga T790M. Te Whakamutunga: Ko nga kitenga e tohu ana ko te β-Catenin he mahinga rongoa hou i roto i te NSCLC whakawhitiwhiti EGFR e kawe ana i te whakawhitinga T790M. 4-Chloro-6,7-dimethoxyquinazoline(13790-39-1) Specifications CAS 13790-39-1 CAS Min% 95.0 CAS Max% 100.0 Tau MDL MFCD01570172 Ki te KAUPAPA KI LLLHRNQLGUOJHP-UHFFFAOYSA-N Ingoa Toiina, Rauemi ranei 4-Chloro-6,7-dimethoxyquinazoline Hauira Purapura Motuhēhē Puka Puka Powder or Chunks Packaging Pounamu tio Tātai rāpoi C10H9ClN2O2 Taumaha Taumaha (g / mol) 224.65 Tuhinga o mua COC1 = C (C = C2C (= C1) C (= NC = N2) Cl) OC Tae White ranei tata ma te mana Ko te Whakakuku 184-187 ° C anga matou 98% 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) Te Haumaru me te Whakaaetanga (13790-39-1) Te whakaahuatanga haumaru: ♦ Ko te mamae o te kiri. ♦ Ko te ahua kino o te kanohi. ♦ Ka meinga e koe te mamae o te hauhanga. (13790-39-1) Te korero whakatupato: ♦ Ahanoa i te pupuhi i te puehu / te paowa / te hau / te kohu / vapors / pupuhi. ♦ Te wero i nga karauna tiaki / te tiaki / te tiaki kanohi / kanohi. ♦ I TE WHAKANUI: Whakanohohia te wai mo te meneti mo etahi meneti. Tangohia nga arotahi whakapiri, ki te mea kei te noho me te ngawari ki te mahi. Haere tonu ki te horoi. ♦ I TE WHAKAMAHI: Tangohia ki te hau hou me te okioki i te waahi pai mo te hau. ♦ Tiaki kua kati. ♦ Tuhia nga ihirangi / putea kia rite ki nga tikanga o te rohe / rohe / motu / ao. WHAKATŪPATO: Ko nga korero i whakawhiwhia ki tenei pae tukutuku i whakawhanaketia i raro i nga ritenga o te ture a te Euroopu (EU) me te tika ki to maatau mohio, korero me te whakapono i te ra i tuhia ai. Ko nga korero i homai i hangaia hei awhina mo te whakahaere me te whakamahi haumaru. Kaore e whakaarohia he waahana, he kounga kounga. 4-Chloro-6,7-dimethoxyquinazoline(13790-39-1) Articles RK Narla; XP Liu; DE Myers; me FM Uckun. 4- (3'-Bromo-4'hydroxylphenyl) -amino-6,7-dimethoxyquinazoline: he tuhinga tawhito quinazoline me te mahi kaha ki te hanga i te haurangi tangata. Clin Cancer Res. 1988, 41405. Chappie, TA, et.al. Ko te Discovery of a Series of 6,7-Dimethoxy-4-pyrrolidylquinazoline PDE10A Inhibitors † .J. Med. Chem. 2007, 50 (2), 182-185. 4-Chloro-6,7-dimethoxyquinazoline(13790-39-1) Technical Service: Kei to tatou kapa o nga kaitaiao nga wheako ki nga waahanga katoa o te rangahau, tae atu ki te Life Science, Te Hangarau Rauemi, te Hinengaro Hinairo, te Chromatography, te Tatauranga me etahi atu. 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) Whakahua Puku & Tauira: Me nui ake nga waahanga mo to whakawhanaketanga, mahi mahi, rangahau ranei? ingoa hua ingoa * īmēra * waea Whakaahua * CAPTCHA * = karere tuku arotake 1 hoki 4-Chloro-6,7-dimethoxyquinazoline(13790-39-1) APICMO - 12 / 10 / 2018 I APICMO, ka whakauruhia e matou te 4-Chloro-6,7-dimethoxyquinazoline i roto i te rahi mo te rangahau rangahau, whanaketanga, whakawhitinga ranei. Ko te punaha whakahaere kounga o nga hua katoa e rite ana ki te cGMP. 4-Chloro-6,7-dimethoxyquinazoline Whakaahuatanga Ko nga kaitautoko o te tipu o te tipu (EGFR) e kitea ana i roto i nga raupapota pukupuku mate pukupuku o te pūtau (NCLC) kei te taumata tiketike o te β-Catenin oncogene. Kei te whakauruhia tenei waahanga i te tohu a Wnt / β-Catenin me te whakapuaki i te pukupuku pukupuku kino, te pathogenesis, me te haere tonu. E whakautu ana nga rerekētanga EGFR ki nga inhibitors tyrosine kinase, ki te EGFR-TKI rānei. Ko te suppressor β-Catenin (XAV939) e hangaia ana nga raina waea ki te EGFR-TKI ma te whakakore i te tohu me te whakarei ake i te EGFR phosphorylation. Mo te whai hua nui, ko enei kaipupuri e rua he pai te taunekeneke, me te hanga i tetahi EGFR-TKI. Ko te XAV939 me te EGFR-TKI e kore e taea te whakahaere i nga pūtau ira NSCLC, kua whakawhanakehia te aukati i te codon T790M. Ko te taukati o te β-Catenin he painga-te whakakaha i te kaha i roto i nga puurohiko o te kohinga pūtake o te tipu me te whakawhitinga T790M. Ko te hanganga hanganga o 4-Chloro-6,7-dimethoxyquinazoline: [Tapanga id = "attachment_700" hāngai = "alignnone" whanui = "500"] 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) - APICMO [/ tapanga] 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) Specifications Ko te pupuhi (˚C) 345.5 Kore CAS. 13790-39-1 Ingoa matū 4-Chloro-6,7-dimethoxyquinazoline Te tihi (g / cm 3 ) 1.321 He tauira tahua C 10 H 9 ClN 2 O 2 Ko te tohu Flash (˚C) 162.77 Ingoa IUPAC 4-Chloro-6,7-dimethoxyquinazoline Ko te ngao teitei (˚C) 184 - 187 Ko te taimaha o te koenga (g / mol) 224.644 Momoisotopic papatipu (g / mol) 224.035 Te āhua taiao mārō viivii 98% Te tahua hanganga Ngā Synonyms · 6,7-dimethoxy-4-chloroquinazoline · Quinazoline, 4-chloro-6,7-dimethoxy- · 4-chloro-6,7-dimethoxy-quinazoline Ngā Āhuatanga Tinana me te Matū o 4-Chloro-6,7-dimethoxyquinazoline 13790-39-1 Haumaru Ko te 4-Chloro-6,7-dimethoxyquinazoline kei te wai kaore i te wai, engari kei te wera i te methanol wera. hononga Te waihanga wai Kaute nama - kahore Whakaaetanga Whakaaetanga - 4 Koha 1 Taea taapiri 2 ahua Ko te 4-Chloro-6,7-dimethoxyquinazoline he ma ki te puehu tioata. 13790-39-1 Whakaritea Whakamahia Ingoa Tae Te uara rawa XLogP3-AA 2.4 Te pehanga tere (mmHg) 0 i 25 ° C Te Tae Tae Tae Taehia Kore 0 Te Tautuhi Tae Akerangi Atomorekore 0 Te horahanga polar mata 44.24 A ^ 2 Taurangi tohu 1.605 Atomope Atom Te tatau 0 Maatau Atom Count 15 Tae Whaimana 0 Makano (g / mol) 224.035 Tae Tae Tae Tautuhia 0 Tautuhia te Tohu Toro o Atom 0 He Canonicalized te tohu Ae Tuhinga 218 Whakatairanga i te Rohe Hinanga o 4-Chloro-6,7-dimethoxyquinazoline Nga Rohe Atu: 13790-39-1 Precursors Kore CAS. Ingoa matū Te tahua hanganga 184764-63-4 2H-pyrazolo[3,4-d]pyridine-4,6(5H,7H)-dione 50270-27-4 2,4,6-trichloropyrimidine-5-carbaldehyde 7727-37-9 Dinitrogen 2465-59-0 Alloxanthine 4-Chloro-6,7-dimethoxyquinazoline Products Downstream Kore CAS. Ingoa matū Te tahua hanganga 99979-82-5 6-amino-1,2-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-thione 6288-85-3 6-chloro-4-methylsulfanyl-1H-pyrazolo [3,4-d] Pyrimidine 7251-92-5 6-chloro-N-methyl-1H-pyrazolo [3,4-d] pyrimidin-4-amine 7508-59-0 6-chloro-1,2-dihydropyrazolo [3,4-d] pyrimidine-4-thione 5417-80-1 6-chloro-4-ethylsulfanyl-1H-pyrazolo [3,4-d] Pyrimidine 2537-04-4 6-amino-1,2-dihyderopyrazolo [3,4-d] pyrimidin-4-one 5444-28-0 N-methyl-6- (methylsulfanyl) -1H-pyrazolo [3,4-d] pyrimidin-4-amine 7152-45-6 6- (dimethylamino) -1,2-dihydropyrazolo [3,4-d] pyrimidine-4-thione 5417-81-2 2-[(6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino)ethanol 42754-97-2 6-chloro-1,2-dihydropyrazolo [3,4-d] pyrimidin-4-one 98277-30-6 4,6-dimethoxy-1H-pyrazolo [3,4-d] pyrimidine 5417-78-7 6-chloro-1H-pyrazolo [3,4-d] pyrimidin-4-amine Nga tono a 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) He waitohu whakawaiwai, he takahanga nui i roto i te hanga o nga hua tipu o te tipu Nama Nama 13790-39-1 Ko te nuinga ake pea ka whakapouri i te kiri Ka arahina atu ki te mamae o nga kanohi Ka whakapouri i te pūnaha hauora He kino ki te kiri Ko te 20% pea ka pangia te mate kino ki runga i te horomanga me te whakauru Nga Whakatupato I te Whakaaetanga ki te 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) 1. Parenga Whaiaro Nga taputapu tiaki Whakamahia he rehuhuhuhuhuhuhuhurahu, he karapu peera, he matapihi kanohi tiaki, me nga matapihi haumaru. Me whakaaetia enei taputapu katoa e te kawanatanga o te kawanatanga me nga paerewa haumaru o te ao. Te mana whakahaere Tāutahia te whakakorenga o te whakamohoatanga me te taputapu horoi mo te hau hei whakaiti i te rongo ki te puehu, te pungarehu, me etahi atu haurangi o te hau. Ko te whare taiwhanga kia pai te whakakotahi i te wairere me te haumaru o te kanohi. 2. Nga Mahi Awhina Tuatahi Inhalation Whakahokia te tangata i te patunga ki tetahi rohe me te nui o te rererangi rangi. Ki te mea he uaua te manawa, ka uru ki te taangata. Ko nga tohu nui ka karanga mo te rongo. Whakawhiti kiri Mai i nga tohu whakatupato P302, P313, P332, me P352 horoi i te rohe motuhake me te nui o te wai rere me te hopi. Rapua he tohutohu hauora i te take o nga mate mate kino. Ingoa Eiaha e tamata i te haapuai i te vomiting. Horoihia te mangai me te tango i te toru kapu o te wai makariri me te waiu. A, no te kore e mate, whakapā atu ki tetahi pokapū kawa ranei, ki te rata ranei. Whakaaetanga kanohi Tangohia nga arotahi whakapiri ki te taea ki te horoi i nga kanohi me te nui o te wai makariri. Me mahi tenei mo te iti rawa o nga meneti 15 me te whiwhi hauora hauora. Ko enei taurangi whakatupato i runga i nga P305, P337, P338, me P351. 3. Te whakahaere 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) A, no te whakamahi i te hua, mahara ki nga korero whakatikatika e whai ake nei: Whakanohoia nga taputapu tiaki tika Kaua e pupuhi te puehu, te wera, te hau, te hau ranei Te mahi i roto i te waahanga i te waahanga, i te waahanga taiao ranei Ko te whakakore i te puehu o te puehu ma te whakamahi i te horoinga rohe 4. Te rokiroki o 4-Chloro-6,7-dimethoxyquinazoline Mo te rokiroki tika o te hua, kia mohio ki te mahi i nga mea e whai ake nei: Tiakina i roto i te waahi hauora me te waatea Tiakina te hua i roto i te oko hiri Ahanoa i te kite ki nga kaihautuku pitihana Katihia te rokiroki Whakaorangia te 4-Chloro-6,7-dimethoxyquinazoline i te pāmahana rūma 5. I muri Whakamahia I muri i te whakamahi 4-Chloro-6,7-dimethoxyquinazoline: Kia mau ki te whakapaipai whaiaro tika ma te horoi i nga ringa me nga kakahu maeneene Whakapaia te pae mahi Te tuku i nga ururua i runga i nga paerewa o te rohe Hokihia te toenga ki te putea taketake taketake 6. Nga Mahi Tiaki Ko te 4-Chloro-6,7-dimethoxyquinazoline kei runga i te wera, te wera, te ngaohihana tiketike ranei, te whakaputa i te waiu kawa. Ko nga hua o te wera ko te mono mono, te waikawa waikawa, te waikawa hauota, me te CO ^ 2. Whakanohoia nga taputapu pai ina maka ana te ahi. Whakamahia te konupuku hāora, te wai waipiro, te waipiro polymer, te haukene matū maroke ranei i te mahi i te taha hau. 7. Nga waahi Aukati i nga pounamu me nga rerenga mai i te whakauru mai i nga awaawa o te tau. Motuhia te puehu, te mimiti i nga wai, me te tiki i nga pokaika mahinga ka kohia ki roto i te pouaka rererangi. Te horoi i te rohe ma te horoi me te whakawhiti. Te tuku i te whakamahinga o nga hua whakapoke i runga i nga whakaritenga ture. 8. Te maatau me te whakahenga o 4-Chloro-6,7-dimethoxyquinazoline Ko te 4-Chloro-6,7-dimethoxyquinazoline e mau ana i raro i nga tikanga whakahaere. Ka tukuna noa iho ki te whakaatu ki nga hopi pitihana, ki te wera, ki te wera nui ranei. Ko te urupare o te hua e kore e pangia i tetahi ara. 9. 13790-39-1 Rangahau Toi Tuhia te 4-Chloro-6,7-dimethoxyquinazoline i muri i nga ture o te rohe. Me mahi tahi me tetahi kaiwhakarato ratonga raihana raihana hei awhina i te whakakore i nga hua otaota. Engari, ka tahu i roto i te kaituhi, e tika ana mo te kapi me te kapi. 10. Mōhiohio Shipping Ko te 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) he mea korerea mo nga mahinga kaipuke katoa. Raraunga Ture Ko te 4-Chloro-6,7-dimethoxyquinazoline kahore he matū haumaru. He haumaru mo te whakamahinga whakamatau. Taipitopito Hangarau Ko o mätou kaimätai pütaiao he matatau ki ngä take pütaiao katoa, tae atu ki te ora me te matatini matatini, te rangahau matū, te whakawhäinga hua, te kimi rongoä, me ëtahi atu wähi e hängai ana. 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) Te Putea me te utu Kei te rapu 4-Chloro-6,7-dimethoxyquinazoline (13790-39-1) i roto i te rahi mo to rangahau rangahau me te whakawhanaketanga? Whakapā atu ki te kaihoko a APICMO mo te korero. Bibliography Desmond J. Brown, John Wiley & Sons, Quinazolines, Whakamutunga 1, 17 Sep 2009 - Pūtaiao, whārangi 670- 700. William Andrew Publishing, Pharmaceutical Manufacturing Encyclopedia, Elsevier, 22 Oct 2013 - Medical, whārangi 38-47. National Center For Information Biotechnology, US. National Library of Medicine, Pubchem, 4-Chloro-6,7-dimethoxyquinazoline, Wāhanga 1-10. Tāpiri i te arotake Whakakore whakautu Ka kore e whakaputaina tō wāhitau īmēra. tō whakatauranga Auau ... tino Pai Toharite E kore e kino Tino rawakore tō arotake * ingoa * īmēra * e pā ana Products 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine (90213-66-4) na APICMO Pānuitia atu 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine (42754-96-1) na APICMO Pānuitia atu 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) na APICMO Pānuitia atu Rapu hoki: Rapu Ngā Kāwai Hua Pūhui Spiro Azetidines Heterocycles Nga potae Nga pounamu Qungazolines Nga pungarehu Ngā pūhui chiral Ētahi atu pūhui Orthe Tūtohu hua Tuhinga Kāwai Tuhinga Kāwai Tīpako Kāwai Ko te tuhinga CMO (2) Ko te matauranga hauora (7) Nga Releata Hou 2019 CNS Treatment Drug Monosialotetrahexosylganglioside Sodium (GM1) Pig Brain (37758-47-7) 06 / 05 / 2019 Ko nga mea katoa e hiahia ana koe ki te mohio ki nga Pyridines 08 / 30 / 2018 Ko te nuinga o nga Taonga Hiko o te Ao 08 / 28 / 2018 Ko nga mea katoa e hiahia ana koe ki te mohio ki nga waehui spiro 08 / 28 / 2018 2-Chloro-5-methylpyrimidine: CAS (Ratonga Tapeke Tika) Waitohu 22536-61-4 08 / 18 / 2018 APICMO - Pakihi, APICMO & Pharmaceutical te hoko NOW Ko APICMO he kamupene rongoa kei te whanake i nga kaiwawao matua o nga raau hou. Kei te arotahi ki te whakarato i te raupapa katoa o nga ratonga whakahiato me te whakarite mo nga rangahau raau taero me nga pokapü whanaketanga me nga kamupene rongoa. Products Ētahi atu pūhui Nga pounamu Heterocycles Qungazolines Nga potae Ngā pūhui chiral Azetidines Nga pungarehu Pūhui Spiro to tatou Ratonga Ko te whakawhitinga ahurea me te kirimana R & D Pauna iti me te raupapa whakahau Poraka whare mo te kitenga raau taero Tukatuka R & D me te whanaketanga huarahi hou Whakapā mai Te hanga D, te papa 2, Nama 128, Road Xiangyin, Takiwa o Yangpu, 200433, Shanghai, Haina + 86 (1812) 4514004 [Tiakina email] © Copyright 2019 APICMO. 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