4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde(918515-16-9) -APICMO Ko APICMO he kaiwhakarato o te hanganga ritenga ahumahi me te kirimana R & D Kāinga Mō Us To tatou Tikanga to tatou kiritaki To tatou Team to tatou Ratonga Rangahau me te kirimana R & D Te ahumahi iti me te ahumahi nui Poraka whare mo te kitenga raau taero Tukatuka R & D me te whanaketanga huarahi hou Tukuangé press Products Whakapā mai Kāinga Mō Us To tatou Tikanga to tatou kiritaki To tatou Team to tatou Ratonga Rangahau me te kirimana R & D Te ahumahi iti me te ahumahi nui Poraka whare mo te kitenga raau taero Tukatuka R & D me te whanaketanga huarahi hou Tukuangé press Products Whakapā mai Hua Products > 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) Kei te noho tenei hua (s) i runga i te kirimana APICMO. Ko te kaha ki te whakaputa, te whakahiato me te waihanga i te rahi o 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) me te pūnaha whakahaere kounga i raro i te hangahanga CGMP ture. Kāwai: Heterocycles Whakaahuatanga Reviews (1) Whakaahuatanga 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) video Ko Janus kinases (JAKs) te mahi nui ki te whakawhitinga tohu tohu whakawhitiwhiti i waenga i te cytokine. Kua puta mai nga kaiwhakatere a JAK hei kaihautū moemoeke whai hua mo te ārai i te whakaheke o te rerenga. I whakaaturia e matou i mua atu ko te imidazo-pyrrolopyridinone 2 he kaha aukati JAK; Heoi, he iti te whakamahinga waha waha i runga i te ngoikore o te membrane. I konei, ka whakaatuhia e matou te whakarereketanga hanganga o te 2 hangarau ki roto i te 18a dipyrrolopyridine tricyclic e arotahi ana ki te whakaiti i te rohe poari (PSA), e whakaatu ana i te ngohe i roto i te vitro, te pai ake o te membrane me te koiora ora. Ko te tohu 18a i whakaatu i te kaha i roto i te tauira o te whakapapa mate pukupuku heterotopic. Kei te noho tenei hua (s) i runga i te kirimana APICMO. Mena kei te tiro koe i tenei whārangi hei kaiwhakamahi kore-rēhitatia, ko te utu (s) e whakaatuhia ana ko te Utu Rārangi. Hei tiro i to utu, takiuru ma te whakamahi i to tau nama, ka riro hei kaiwhakamahi rēhitatia mā te whakapā atu ki tetahi o o tatou ratonga Ratonga Kiritaki. Ki te whakatakoto i tetahi tono, whakapā atu ki te Ratonga Kiritaki a APICMO. 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) Specifications CAS 918515-16-9 CAS Min% 95% CAS Max% 100% Tau MDL MFCD09880129 Ki te KAUPAPA KI DYWWVLQMUUZZRJ-UHFFFAOYSA-N Ingoa Toiina, Rauemi ranei 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde Hauira Purapura Motuhēhē Puka Puka White ki te parauri parauri Packaging Pounamu tio Tātai rāpoi C8H5N2OC Taumaha Taumaha (g / mol) 180.594 Tuhinga o mua ClC1 (= C2 (C (= NC = C1) NC = C2C = O)) Tae White Te wai kohua 372.6 ° C i 760 mmHg anga matou 98% 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) Te Haumaru me te Whakaaetanga Kaua e pupuhi te puehu, te wera ranei. Kia pai te horohi me te horoi kanohi. Kaua e uru ki nga kanohi, ki te kiri, ki te kakahu ranei. Kia mau tonu te pouaka. Tiakina i roto i tetahi wahi hauora, maroke, waahi pai. Me whakarite he hauora tika i te wa e whakamahia ana. Whakamahia anake i roto i te hopi matomato. WHAKATŪPATO: Ko nga korero i whakawhiwhia ki tenei pae tukutuku i whakawhanaketia i raro i nga ritenga o te ture a te Euroopu (EU) me te tika ki to maatau mohio, korero me te whakapono i te ra i tuhia ai. Ko nga korero i homai i hangaia hei awhina mo te whakahaere me te whakamahi haumaru. Kaore e whakaarohia he waahana, he kounga kounga. 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) Articles Te kitenga o nga tiwhikete dipyrrolopyridine tricyclic rite te pukapuka JAK Ko Janus kinases (JAKs) te mahi nui ki te whakawhitinga tohu tohu whakawhitiwhiti i waenga i te cytokine. Kua puta mai nga kaiwhakatere a JAK hei kaihautū moemoeke whai hua mo te ārai i te whakaheke o te rerenga. Te Biomiora me te Maimoatanga 2017 Ko te tohu me te aromatawai koiora o nga korero a pyrrolo [2,3-b] pyridine rite nga kaitautoko antiproliferative me to ratou taunekeneke ki te DNA wheehe DNA He raupapa o toru tekau e rua pyrrolo pūrākau [2,3-b] analogues pyridine synthesized, āhuatanga (1H NMR, 13C NMR ko MS) me te aro mātai cytotoxic o enei rāpoi ngota kawea i roto i runga i te rōpū o toru ngā rārangi pūtau pukupuku tangata tae atu A549 Ko te Rangahau o te Maturanga Rangahau o te Iwirangi a 2016 Ratonga Hangarau: Kei to tatou kapa o nga kaitaiao nga wheako ki nga waahanga katoa o te rangahau, tae atu ki te Life Science, Te Hangarau Rauemi, te Hinengaro Hinairo, te Chromatography, te Tatauranga me etahi atu. 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9) Whakahua Puku & Tauira: Me nui ake nga waahanga mo to whakawhanaketanga, mahi mahi, rangahau ranei? ingoa hua ingoa * īmēra * waea Whakaahua * CAPTCHA * = tākupu tuku arotake 1 hoki 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9) APICMO - 12 / 10 / 2018 I APICMO, ka whakarōpūhia, ka waihangatia te nui o te 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde, i roto i era atu matū. Ko o tatou hua e whai ana ki nga paerewa ahumahi CGMP, he nui hoki te rangahau, te whanaketanga, me te whakaputa. 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde Whakaahuatanga Kaore a JAKs, Janus ranei, e takahi ki te whakawhitinga tohu tohu whakawhitiwhiti o te cytokine. Kua tautuhia e te rangahau nga kaipupuri o te JAK kia waiho hei kaihauturu, ka awhina i nga rejections o te tipu. I te tuatahi, ko te imidazo-pyrrolopyridine2 tricyclic ko to tatou kaipupuri o te JAK runga noa ake kia kitea ra ano he ngoikoretanga o te membrane e whakaheke ana i te whakamahinga o te waha. Ko te whakarereketanga o te hanganga i runga i te imidazo-pyrrolopyridine 2 e whakaiti ana i te rohe o te polar, na reira, ka ara ake ki te tricyclic imidazo-dipyrrolopyridine. Ko tenei punaha kua tino pai ake te manawanui ki te whakamahinga o te waha o te waha, me te itexhibits mahi kaha vitro. I te wa e whakahaeretia ana i roto i te tauira rerenga mate a te kiore, he tino whai hua. (918515-16-9) Whakatakotoranga Hua Ngā Synonyms · 4-Chloro-7-azaindole-3-carbaldehyde · 4-Chloro-3-formyl-7-azaindole Te tahua hanganga viivii 98% pure Te āhua taiao mārō Momoisotopic papatipu (g / mol) 180.009 Ko te taimaha o te koenga (g / mol) 180.591 tātai rāpoi ngota C 8 H 5 ClN 2 O Ko te tohu Flash (˚C) 179.1 Te tihi (g / cm 3 ) 1.521 Ingoa matū 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde Kore CAS. 918515-16-9 Ko te Puku (˚C) 372.6 i 760 mmHg 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde Te Ahupūngao me te Āhuatanga Tinana o pūmautanga Ko te 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde i raro i nga tikanga noa. Heoi, ko te whakawhitinga o te hua ki nga huamahana tiketike, te makuku, te kaha ranei o nga hopi pitihana hei whakaeke i te waahi. 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde hononga Te waihanga wai Tau nama - 1 wae Ko te Kaitango Whakaaetanga - Nga wae 2 Koha Taea taapiri 1 ahua Ko te 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde he maama parauri-ma. 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9): Computed Properties Ingoa Tae Te uara rawa Tuhinga 188 He Canonicalized te tohu Ae Tautuhia te Tohu Toro o Atom 0 Tae Tae Tae Tautuhia 0 Ko te tipu o te vaporization (kJ / mol) 61.97 Makano (g / mol) 180.009 Tae Whaimana 0 Maatau Atom Count 12 Atomope Atom Te tatau 0 Ko te rohe Polar (PSA) 45.75 A 2 Taurangi tohu 1.748 Huringa taiao (dyne / cm) 71.9 Te horahanga polar mata 45.8 A ^ 2 Te Tautuhi Tae Akerangi Atomorekore 0 Te Tae Tae Tae Taehia Kore 0 Te pehanga tere (mmHg) 9.53E-6 XLogP3-AA 1.4 Rohe Rohe o 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde Kei raro nei nga tikanga e rua hei whakarahi i te hua: 4-Chloro-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde (918515-16-9): Uses Ko te hua he takawaenga rongoa, e mahi ana i te aukati a JAK hei aukati i te whakaheke i te tipu Nga Maamaa e Ngaohi ana ki te 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde He kino i te wa e werahia ai, ka arahi ai i te mamae o te manawa, te ngoikore o te manawa, te tausea ranei Ka puta te kino, te whero, te mamae ranei o te kiri i te wa e tika ana te whakapiri He kino i te wa e horomia ana, e arai ana i te mate kino Te mamae o te kanohi, te kino kino ranei Nga waahi haumaru ina pa ana ki te 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde 1. Parenga Whaiaro Whakanohia he kanohi ki te whakakii i te hau ki te whakakore i nga whaeratanga ohorere, ka whakakorekore i te waahanga rewharewha.Mo o ringa me o waewae, ka mau ki nga totikota matū me te potae herenga, ia. Whakanohia he huinga tinana katoa hei hipoki me te tiaki i te kiri. 2. (918515-16-9): Mana Whakahaere Me whakarite i to rohe mahi me te hopi paraoa, nga potae, nga taputapu mo te hau, te haumaru haumaru, te uira, me nga kaapena kawenata. 3. Nga Mahi Awhina Tuatahi Inhalation Murihia te waha mo nga meneti 10. Inumia te nui o te wai ki te hawhe rita. Mena kei te tamau tonu nga tohu, whakapä atu ki tetahi pokapū kawa ranei, ki te rapu ratonga hauora ranei. Whakawhiti kiri Tangohia he kakahu pokekore tonu. Horoihia te waahanga e pa ana ki te wai rere mo nga meneti 15. Rapua te aro o te rongoa i roto i te ahua ka haere tonu nga tohu. Inhalation Whakanuia te patunga ki tetahi ruma me te nui o te hauora me te waahi o waho. Mena ka kaha nga tohu kaore e pupuhi ana, ka whakahaerehia te awhina o te hauora me te korero ki tetahi ngaio hauora. Whakaaetanga kanohi Tangohia nga arotahi whakapiri mēnā kei a koe. Whakamahia nga kanohi ki te nui o te wai mo nga meneti 10 e whai mai nei. 4. I te whakamahi i te 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde I te wa e whakamahia ana te hua, whakaarohia nga take i raro nei: Whakamahia i roto i te hohi whakakii Whakanohoia nga taputapu haumaru kia rite ki nga paerewa haumaru mahi a te rohe me te taone Mahi i roto i te ruma me te hauora nui 5. I muri Whakamahia I muri i te whakamahi i te 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde, he tauira enei hei tango: Whakaorangia nga toenga i raro i nga wera iti Tuhia nga kete me nga toenga o te koree Me horoi o ringaringa Tangohia nga kakahu poke, horoia i mua i te whakamahinga 6. A, no te Whakamahia A, no te kore e whakamahi, Katihia te matū i roto i te hiri hiri hei whakaiti i te uru Kia mau ki te pouaka A karo i te whakaatu ki te wera me etahi atu matū 7. 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde Kohikohi me te Whakanoho Storage Kia mau ki te pouaka, kia pai i -20˚C Tiakina i roto i nga pouaka kati Tuhia ki te taiao hauora, maroke hoki Katihia te matū i roto i nga kaitaina hiri hei aukati i te uru kore whāwhā Whakanohoia nga taputapu tiaki whaiaro Whakamahia i roto i te hopi matomato Te mahi i roto i te waahi o waho, i te ruma pai ranei Kaua e whakakore i nga parai, te hau, te puehu, te atu ranei 8. Mana Mana Whakanohoia nga kakahu tiaki me nga taputapu manawa. Whakamotitia te mura ki te pupuhi, te konupora hauora, te paura maroke ranei. Ko nga hua whakawera o 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde kei roto i nga waikura o te hauota, te HCl, me te monoxide konupora. 9. Te whakahaere i nga putea I roto i te ahua wai, whakauruhia ki te mea whakauru i roto i te wairangi, te horoi, me te tuku i roto i te kohinga me te kati. Mo te tautuhi pakari, tangohia te matū me te whakakore i te reira. Kaua rawa e tukua nga waahi kia kite i to raatau ara i roto i nga awa wai, i nga awaawa ranei. 10. Te Ahumahi Hauora me te Reactivity 11. Te Whakarutanga Rawa Whakamahia te 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde hei otaota motuhake me te tuku i nga whakaritenga o te whakakore i nga otaota ururua o te takiwa / rohe / paatete. A, no te whakamahi i nga ratonga a te kamupene o te rohe, me whakarite kia rēhitatia, kia raihana hoki. 12. 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9): Mōhiohio Shipping Kaore he haumaru e mohiotia ana ko te rererangi o te rangi, o te whenua ranei o 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde. Ture Whakahaere Ko te kohinga me te taumata paepae o te 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde e whai ana ki te uara iti o te waahanga SARA Title III o te 302 me te 313. 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde: Taipitopito Hangarau Ko o tatou rangahau rangahau he wheako nui rawa atu i roto i nga rauemi matatini me te ora, te rangahau matū, te whakawhitinga, me te chromatography. 4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde (918515-16-9): Te Whakatairanga me te Whakatauranga Nui Mena ka hiahia koe ki te 4-Chloro-1H-pyrrolo [2,3-b] pyridine-3-carbaldehyde i roto i te rahi, mo to rangahau me to whakawhanaketanga, tuhia taau whakatau ki a maatau ma te whakapiri atu ki to ratonga manaaki kaihoko. Bibliography National Center For Information Biotechnology, US. National Library of Medicine, Pubchem4-Chloro-1h-pyrrolo [2,3-b] pyridine-3-carbaldehyde, Kohinga 1-10 Naoki Katsuki, Shumpei Isshiki, Juan Okamura, Kouji Kuramochi,, me Kazunori Tsubaki Ko te Journal of Organic Chemistry 2017 82 (21), 11563-11572 Ihle JN, Thierfelder W, Teglund S, et al. Te waitohu na te kaitautoko o te kaitangi o te cytokine. Ann NY Acad Sci. 1998; 865: 1-9 Tāpiri i te arotake Whakakore whakautu Ka kore e whakaputaina tō wāhitau īmēra. tō whakatauranga Auau ... tino Pai Toharite E kore e kino Tino rawakore tō arotake * ingoa * īmēra * e pā ana Products Tetrahydro-4-pyranol (2081-44-9) na APICMO Whakatauria 5.00 i roto i o 5 Pānuitia atu 2,4-Dichloropyrido[3,4-d]pyrimidine (908240-50-6) na APICMO Pānuitia atu 6-Chloro-5-azaindole (74976-31-1) na APICMO Pānuitia atu Rapu hoki: Rapu Ngā Kāwai Hua Pūhui Spiro Azetidines Heterocycles Nga potae Nga pounamu Qungazolines Nga pungarehu Ngā pūhui chiral Ētahi atu pūhui Orthe Tūtohu hua Tuhinga Kāwai Tuhinga Kāwai Tīpako Kāwai Ko te tuhinga CMO (2) Ko te matauranga hauora (7) Nga Releata Hou 2019 CNS Treatment Drug Monosialotetrahexosylganglioside Sodium (GM1) Pig Brain (37758-47-7) 06 / 05 / 2019 Ko nga mea katoa e hiahia ana koe ki te mohio ki nga Pyridines 08 / 30 / 2018 Ko te nuinga o nga Taonga Hiko o te Ao 08 / 28 / 2018 Ko nga mea katoa e hiahia ana koe ki te mohio ki nga waehui spiro 08 / 28 / 2018 2-Chloro-5-methylpyrimidine: CAS (Ratonga Tapeke Tika) Waitohu 22536-61-4 08 / 18 / 2018 APICMO - Pakihi, APICMO & Pharmaceutical te hoko NOW Ko APICMO he kamupene rongoa kei te whanake i nga kaiwawao matua o nga raau hou. Kei te arotahi ki te whakarato i te raupapa katoa o nga ratonga whakahiato me te whakarite mo nga rangahau raau taero me nga pokapü whanaketanga me nga kamupene rongoa. Products Ētahi atu pūhui Nga pounamu Heterocycles Qungazolines Nga potae Ngā pūhui chiral Azetidines Nga pungarehu Pūhui Spiro to tatou Ratonga Ko te whakawhitinga ahurea me te kirimana R & D Pauna iti me te raupapa whakahau Poraka whare mo te kitenga raau taero Tukatuka R & D me te whanaketanga huarahi hou Whakapā mai Te hanga D, te papa 2, Nama 128, Road Xiangyin, Takiwa o Yangpu, 200433, Shanghai, Haina + 86 (1812) 4514004 [Tiakina email] © Copyright 2019 APICMO. 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